The Intrinsic Dissolution Apparatus provides the dissolution rate of a pure active pharmaceutical ingredient (API) by exposing the API to a constant surface area of dissolution medium. The intrinsic rate is determined by rotating the apparatus in a dissolution vessel containing 37 °C media and pulling samples until at least 10% of the API has dissolved. The rate is then calculated by plotting the cumulative amount of API dissolved from the exposed surface area with respect to time.
The Dissolution Source Book provides information on the Intrinsic Dissolution Apparatus and related accessories.